AMINO ACID LIPIDS Russian patent published in 2018 - IPC C07C237/08 C07C237/22 C07C237/30 C07C271/22 A61K9/127 

FIELD: medicine.

SUBSTANCE: invention relates to compounds of general formula I which can be used as a carrier in drug delivery systems or for the indication of antibodies. In formula I, Y is O, NH or a covalent bond, P₁ is H, straight or branched alkyl which contains from 1 to 12 carbon atoms optionally substituted with an amide group, additionally substituted with alkoxyaryl, P₂, P₃ are independently of each other H, alkoxycarbonyl, optionally substituted with fluorenyl, or polyoxy(C₂-C₃)alkylene substituted with an amino group and a -CO- group, L is a group of formula (a), in which the dashed line is the point of attachment to N, R₁ is H, R_1' is H, R₂ is H, R_2' is H or a group of formula -OR_d or -CH₂-OR_d, R₃ is H or a group of formula -(CH₂)₂-OR_e or -(CH₂)₃-OR_e, R_a, R_d, R_e are independently of each other a saturated or unsaturated, straight or branched hydrocarbon chain which contains from 6 to 30 carbon atoms, m is 1, 2 or 3, provided that at least one of R₁, R_1', R₂, R_2', R₃ is not H. Invention also relates to a vesicular composition and a kit for use in a drug delivery system, said drug comprising a compound of formula I.

I, (a).

EFFECT: amino acid lipids are disclosed.

13 cl, 7 ex