FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to C5 binding polypeptides, comprising a C5 binding motif, BM, which can be used in medicine. C5 binding polypeptide containing a C5 binding motif BM is obtained, wherein the motif consists of an amino acid sequence corresponding to EX2X3X4AX6X7EIDX11LPNLX16X17X18QWX21AFIX25X26LX28D, and the resulting polypeptide is used to treat a C5 related condition, for example, to inhibit the hemolytic effect.
EFFECT: invention provides improved preparation, purification and stability of a C5 binding polypeptide, which positively affects the treatment of a C5 related condition.
29 cl, 16 dwg, 8 tbl, 12 ex
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|
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|
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