NOVEL POLYPEPTIDES Russian patent published in 2020 - IPC C07K19/00 C07K14/47 C07K14/735 A61K38/16 A61K47/66 

FIELD: biotechnology.

SUBSTANCE: invention relates to dimers of constructed polypeptides binding to a neonatal FcRn receptor Fc containing a FcRn-binding motif EX₂X₃X₄AX₆X₇EIRWLPNLX₁₆X₁₇X₁₈QRX₂₁AFIX₂₅X₂₆LX₂₈X₂₉, where X₂ is selected from A, D, E, F, H, I, K, L, N, Q, R, S, T, V, W and Y; X₃ selected from A, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W and Y; X₄ is selected from A, D, E, F, G, H, I, K, L, N, Q, R, S, T, V, W and Y; X₆ is selected from A, G, K, Q, R, S and V; X₇ is selected from A, F, H, K, N, Q, R, S and V; X₁₆ is selected from N and T; X₁₇ is selected from F, W and Y; X₁₈ is selected from A, D, E and N; X₂₁ is selected from A, S, V and W; X₂₅ is selected from D, E, G, H, I, K, L, N, Q, R, S, T, V, W and Y; X₂₆ is selected from K and S; X₂₈ is selected from A, D, E, H, K, L, N, Q, R, S, T, W and Y; and X₂₉ is D.

EFFECT: present invention enables to obtain fused proteins, conjugates and compositions capable of efficiently binding FcRn.

22 cl, 21 tbl, 25 ex, 18 dwg