C5-BINDING POLYPEPTIDES Russian patent published in 2020 - IPC C07K14/315 C07K19/00 C12N15/09 C40B40/02

Abstract RU 2714156 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a polypeptide comprising a sequence EX₂X₃X₄AX₆X₇EIX₁₀X₁₁LPNLX₁₆X₁₇X₁₈QX₂₀X₂₁AFIX₂₅X₂₆LX₂₈X₂₉X₃₀PX₃₂QSX₃₅X₃₆LLX₃₉EAKKLX₄₅X₄₆X₄₇Q and having higher stability. Present invention also relates to groups of polypeptides-versions based on a common framework, where each polypeptide in a group contains an amino acid sequence EX₂X₃X₄AX₆X₇EIX₁₀X₁₁LPNLX₁₆X₁₇X₁₈QX₂₀X₂₁AFIX₂₅X₂₆LX₂₈X₂₉X₃₀PX₃₂QSX₃₅X₃₆LLX₃₉EAKKLX₄₅X₄₆X₄₇Q, and methods of selecting the desired polypeptide having affinity for a given target.

EFFECT: high stability polypeptide, groups of variant polypeptides and methods for selecting the desired polypeptide having affinity for a given target are provided.

17 cl, 9 dwg, 11 tbl, 13 ex

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RU 2 714 156 C2

Authors

Nordling Erik

Nilsson Joakim

Stromberg Patrik

Dates

2020-02-12—Published

2014-08-28—Filed