FIELD: biotechnology.
SUBSTANCE: invention relates to fusion proteins based on polypeptides specifically binding to the human complement component C5, and can be used in medicine for the treatment of a patient with a complement component C5-mediated disorder. Fusion proteins are proposed that include an engineered polypeptide containing a VHH domain that specifically binds to the human complement component C5, and an engineered polypeptide containing a VHH domain that specifically binds to human serum albumin, fused directly or through a linker.
EFFECT: invention provides for the production of a fusion protein comprising engineered polypeptides that specifically bind to human complement component C5 and serum albumin, respectively, without reducing the binding of serum albumin to FcRn or without reducing the half-life of serum albumin.
22 cl, 12 dwg, 20 tbl, 17 ex
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