FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula I or a pharmaceutically acceptable salt thereof, where R2 is selected from formula II or formula III, wherein Ra is hydrogen or methyl. Invention also relates to a pharmaceutical composition by using the compound of formula I and a method for treating proliferative disorders and acute myeloid leukemia by using the compound of formula I.
I , .
EFFECT: technical result: new imidazopyridine derivatives possessing useful biological properties are obtained.
9 cl, 2 dwg, 5 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
COMPOSITIONS AND METHODS WHICH CAN BE USED FOR TREATING PROLIFERATIVE DISEASES | 2015 |
|
RU2711500C2 |
CHEMICAL COMPOUNDS-759 | 2008 |
|
RU2481348C2 |
BICYCLIC AMINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | 2007 |
|
RU2465275C2 |
PYRAZOLE DERIVATIVES AND THEIR USE | 2020 |
|
RU2805207C1 |
PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS TAM AND MET KINASE INHIBITORS | 2019 |
|
RU2773611C1 |
UREA COMPOUND, A METHOD FOR PRODUCTION THEREOF AND MEDICAL USE THEREOF | 2017 |
|
RU2741596C2 |
IDENTIFICATION OF LKB1 MUTATION AS PROGNOSTIC BIOMARKER OF SENSITIVITY TO TOR-KINASE INHIBITORS | 2011 |
|
RU2565034C2 |
IMIDAZO[1,2-b]PYRIDAZINE AND PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND USE THEREOF AS PROTEIN KINASE INHIBITOR | 2007 |
|
RU2487875C2 |
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | 2006 |
|
RU2387653C2 |
NOVEL COMPOUNDS, USE AND PRODUCTION THEREOF | 2009 |
|
RU2493152C2 |
Authors
Dates
2018-05-25—Published
2013-06-21—Filed