METHOD FOR PRODUCING PYRROLO[2,1-A]ISOQUINOLINES Russian patent published in 2018 - IPC C07D471/04 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, specifically to a process for the preparation of pyrrolo[2,1-a]isoquinolines 3-6, where 3: R₁=OCH₃, R₂=H, R₃=Cl, R₄=H; 4: R₁=OCH₃, R₂=H, R₃=Cl, R₄=CH₃; 5: R₁=R₂=R₃=OC₂H₅, R₄=H; 6: R₁=R₂=R₃=OC₂H₅, R₄=CH₃, comprising the dissolution of 6,7-dimethoxy-3,4-dihydro-1-(4-chlorobenzoyl)isoquinoline or 6,7-diethoxy-3,4-dihydro-1-(3,4-diethoxybenzoyl)isoquinoline in acetonitrile and the addition of 1,5-diphenyl-1-penten-4-yn-3-one or 1-(4-methylphenyl)-5-phenyl-1-penten-4-yn-3-one and 30 mol% of copper (I) bromide and exposure to microwave irradiation (300 W) for 30 min at +200 °C, the residue obtained after completion of the reaction and removal of the solvent is crystallised from the ester. 3-6.

EFFECT: method has been developed for the preparation of pyrrolo[2,1-a]isoquinolines, which may have useful biological properties.

1 cl, 4 ex