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2 575 174

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IPC

C07D471/04(2006-01-01)

A61K31/473(2006-01-01)

A61P15/18(2006-01-01)

(21) (22)

Application

2015108637/04, 2015-03-12

(24)

Start date

2015-03-12

(22)

Actual filing date

2015-03-12

(45)

Published

2016-02-20

(72)

Inventor

Borisova Tat'Jana NikolaevnaVarlamov Aleksej Vasil'EvichVoskresenskij Leonid Gennad'EvichChervjakova Tat'Jana Mikhajlovna

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Obrazovanija Universitet Druzhby Narodov"

METHOD OF OBTAINING DERIVATIVES OF 5,6-DIHYDROPYRROLO[2,1-a]ISOQUINOLINES, WHICH CONTAIN FUNCTIONAL GROUP IN POSITION 2 Russian patent published in 2016 - IPC C07D471/04 A61K31/473 A61P15/18

Abstract RU 2575174 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel method for synthesis of derivatives of 5,6-dihydropyrrolo[2,1-a]isoquinolines, which contain functional group in position 2. Method consists in the fact that 6,7-diethoxy-3,4-dihydro-1-(3,4-diethoxybenzoyl)isoquinoline is dissolved in trifluorethanol with further addition of acrolein, or croton aldehyde, or cinnamon aldehyde, or acrylonitrile and mixing at temperature +70°C, residue, obtained after reaction completion and removal of reagents, is crystallised in mixture of ether with hexane. , 1 R=H, X=CHO; R=CH₃, X=CHO; R=C₆H₅, X=CHO; R=H, X=CN.

EFFECT: increase of prime yield.

4 ex

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RU 2 575 174 C1

Authors

Borisova Tat'Jana Nikolaevna

Varlamov Aleksej Vasil'Evich

Voskresenskij Leonid Gennad'Evich

Chervjakova Tat'Jana Mikhajlovna

Dates

2016-02-20—Published

2015-03-12—Filed