FIELD: chemistry.
SUBSTANCE: invention relates to a novel process for the of 3-amino-substituted 2,3-dihydro-1H-benzo[f]chromenes and 2-amino substituted chromans preparation by of trifluoroacetylchromenes and secondary cyclic amines condensation in a 1:2 molar ratio in methanol solution at room temperature. These compounds are promising for medical chemistry.
EFFECT: this method makes it possible to obtain chroman-2-amines that do not contain substituents at the dihydropyran ring 3 and 4 position, and simplify the process by not having to use an inert atmosphere, expensive and anhydrous solvents.
1 cl, 15 ex
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