FIELD: chemistry.
SUBSTANCE: invention relates to a novel process for the of 3-amino-substituted 2,3-dihydro-1H-benzo[f]chromenes and 2-amino substituted chromans preparation by of trifluoroacetylchromenes and secondary cyclic amines condensation in a 1:2 molar ratio in methanol solution at room temperature. These compounds are promising for medical chemistry.
EFFECT: this method makes it possible to obtain chroman-2-amines that do not contain substituents at the dihydropyran ring 3 and 4 position, and simplify the process by not having to use an inert atmosphere, expensive and anhydrous solvents.
1 cl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 3-ARYL-1H-BENZO[f]CHROMENE DERIVATIVES | 2014 |
|
RU2597363C2 |
| PROCESS FOR PREPARATION OF 1-(1H-BENZOCHROMEN-2-YL)-2,2,2-TRIFLUOROETHANONES | 2016 |
|
RU2662439C2 |
| METHOD FOR PRODUCING 1H-BENZO[F]CHROMEN-2-YL(ARYL)KETONES | 2015 |
|
RU2633368C2 |
| TRIALLILBORANE ADDUCTS WITH AMMONIA AND AMINES AS ALLYLATING REAGENTS | 2018 |
|
RU2678208C1 |
| 4-SUBSTITUTED N-ARYL-1,8-NAPHTHALIMIDES, EXHIBITING PROPERTIES OF FLUORESCENT SENSORS ON METAL CATIONS AND METHODS FOR PRODUCTION THEREOF | 2012 |
|
RU2515195C1 |
| METHOD OF PRODUCING 4-OXO-4H-CHROMENE DERIVATIVES CONTAINING VINYL AND ENAMINE GROUPS | 2011 |
|
RU2468018C1 |
| 1,2,3,6-TETRAHYDROPYRROLO [1,2-d][1,4]DIAZOCINES DERIVATIVES PREPARATION METHOD | 2008 |
|
RU2378279C1 |
| N,N-BIS(2-(DIALKYLAMINO)ETHYL)CARBOXAMIDES AND THEIR DIHYDROCHLORIDES WITH ANTIARRHYTHMIC ACTIVITY AND PHARMACEUTICAL COMPOSITION BASED THEREON | 2017 |
|
RU2645080C1 |
| N-(2-(2-(DIALKYLAMINO)ETHOXY)ETHYL)CARBOXAMIDES AND HYDROCHLORIDES THEREOF, HAVING ANTIARRHYTHMIC ACTIVITY, AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2019 |
|
RU2712638C1 |
| ANTIVIRAL AGENTS AND USE THEREOF | 2015 |
|
RU2730453C2 |
