PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE AND IMPROVED PROCESSABILITY Russian patent published in 2018 - IPC C08B13/00 C08L1/32 

FIELD: chemistry.

SUBSTANCE: invention relates to a polymer comprising hydroxypropyl methyl cellulose acetate succinate (HPMC-AS) wherein a percentage of a total degree of substitution (DS) of succinoyl in position C₆-OH is less than or equal to 6% (C₆ C3_Suc, % ≤ 6%) and in position C₃-OH is from 58 to 84% (58% < C₃ C3_Suc, % < 84%), and percentage of a total DS of acetyl in position C₆-OH ranges from 33 to 51% (33% < C₆ C3_Ac, % < 51%) and in position C₃-OH ranges from 16 to 20% (16% < C₃ C3_Ac, % < 20%). Invention relates to a composition for improving the efficiency and improving the processability of a medicament that comprises a medicament and a said polymer, as well as a process for the preparation of hydroxypropyl methyl cellulose acetate succinate (HPMC-AS) having a percentage of a total DS of succinoyl in position C₆-OH less than or equal to 6% (C₆ C3_Suc, % ≤ 6%) and in position C₃-OH from 58 to 84% (58% < C₃ C3_Suc, % < 84%), and a percentage of a total DS of acetyl, in position C₆-OH of 33 to 51% (33% < C₆ C3_Ac, % < 51%) and in position C₃-OH of 16 to 20% (16% < C₃ C3_Ac, % < 20%), comprising steps of (a) reacting acetic anhydride and sodium acetate with hydroxyl propyl methylcellulose to form an intermediate at a temperature in the range of from about 85 to about 115°C; (b) maintaining the temperature for a period of 30 minutes to 2.5 hours and (c) reacting succinic anhydride with the intermediate product at a temperature for a period of 2.5 to 23.5 hours to obtain HPMC-AS.

EFFECT: increasing the effectiveness of the drug and improving processability.

10 cl, 16 dwg, 11 tbl