FIELD: pharmaceuticals.
SUBSTANCE: inventions relate to a modified CHO cell and a method of reproduction of orthopoxvirus during use thereof. Disclosed cell is modified to include a sequence coding CP77 under the control of a constitutive promoter, and a sequence, coding D13L and/or K1L also under the control of a constitutive promoter. Cell supports the reproduction of poxvirus, which is less able or unable to reproduce in an unmodified CHO cell.
EFFECT: inventions can be used to prepare drugs based on poxviruses (smallpox viruses).
5 cl, 11 tbl, 14 ex
| Title |
Year |
Author |
Number |
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2017 |
|
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| RECOMBINANT STRAIN OF VV-GMCSF-S-Lact VACCINIA VIRUS, WITH ONCOLYTIC ACTIVITY, PRODUCING GRANULOCYTOR-MACROPHAGAL COLONY-STIMULATING HUMAN FACTOR AND SECRETED FORM OF LACTAPTIN ONCOTOXIC PROTEIN |
2016 |
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|
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|
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2023 |
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|
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2006 |
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- Jordan Ingo
- Brundke Ehlizabet
|
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2001 |
- Shchelkunov S.N.
- Rjazankin I.A.
- Ageenko V.A.
- Ignat'Ev G.M.
- Babkin I.V.
|
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2013 |
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- Sene Klod
|
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2007 |
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|
RU2551982C2 |
| ANTIBODY DETECTION METHOD, METHOD OF BLOOD COMPONENT SCREENING, AND ANTI-HCY ANTIBODY DETECTION KIT |
1993 |
|
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2016 |
|
RU2728748C2 |
