VIRAL VACCINES Russian patent published in 2022 - IPC A61K35/76 A61K31/7088 A61P31/12 

FIELD: medicine; infectiology; immunology.

SUBSTANCE: group of inventions relates to the field of medicine, namely to infectiology and immunology, and it is intended for the induction in a patient of a protective immune response to infection with chikungunya, smallpox, and Zika virus. A composition, which induces in a patient a protective immune response to infection with chikungunya, smallpox, and Zika virus, contains a pharmaceutically acceptable carrier and attenuated poxvirus. A poxvirus genome contains a nucleic acid sequence encoding sub-genomic polyprotein 26S of chikungunya virus, and a nucleic acid sequence encoding polyprotein PrME of Zika virus. Attenuated poxvirus is modified poxvirus, wherein the modification includes the deletion of at least one gene encoding endogenous irreplaceable protein of collection or maturation. The use of the specified composition is also presented for the induction in a patient of a protective immune response to infection with chikungunya, smallpox, and Zika virus.

EFFECT: use of the group of inventions allows for the reduction in the risk of infection with chikungunya, Zika virus, and smallpox.

11 cl, 4 tbl, 9 dwg, 3 ex