FIELD: biotechnology, genetic engineering, molecular biology, virology, medicine. SUBSTANCE: invention presents strain of recombinant smallpox vaccine and recombinant plasmid DNA pTBI-HBsAg. Recombinant plasmid DNA encodes nine immunogenic epitopes of two main structural proteins of human immunodeficiency virus of type-1. Recombinant strain of smallpox vaccine modified with plasmid pTBI-HBsAg induces T- and B-cellular immune response against HBsAg and HIV-1 in animals vaccinated by its. Strain can be used as a base for mixed vaccine against HIV-1 and human hepatitis B virus and orthopoxviruses. EFFECT: valuable antiviral properties of strain. 3 dwg, 3 tbl, 3 ex
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Year |
Author |
Number |
| RECOMBINANT PLASMID DNA PC-NS3 PROVIDING INTEGRATION OF COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS 2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN GENOME OF BOVINE VACCINE VIRUS AND RECOMBINANT STRAIN OF BOVINE VACCINE VIRUS EXPRESSING COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN IMMUNIZED ORGANISM CELLS |
1995 |
- Gajnullina M.N.
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- Ignat'Ev G.M.
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- Vorob'Eva M.S.
- Pletnev A.G.
- Beljaev A.S.
- Sandakhchiev L.S.
|
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1993 |
- Frolov I.V.
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- Svjatchenko V.A.
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| VACCINE AGAINST VIRAL INFECTIONS |
2000 |
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|
RU2217162C2 |
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2002 |
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|
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1995 |
- Karpenko L.I.
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- Bajborodin S.I.
|
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2015 |
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2006 |
- Karpenko Larisa Ivanovna
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|
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| RECOMBINANT PLASMID DNA PUHBC ENCODING GENE OF HEPATITIS VIRUS B CORE ANTIGEN PROTEIN AND ENSURING TO EXHIBIT FOREIGN EPITOPES ON THE CORE SURFACE |
1995 |
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|
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|
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