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2 635 105

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IPC

C07D487/10(2006-01-01)

(21) (22)

Application

2016129106, 2016-07-15

(24)

Start date

2016-07-15

(22)

Actual filing date

2016-07-15

(45)

Published

2017-11-09

(72)

Inventor

Tyrkov Aleksej GeorgievichYurtaeva Ekaterina Alekseevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Universitet"

METHOD FOR PRODUCTION OF 4-ARYL-2,7,9-TRIAZASPIRO[4,5]DECANE-6,8,10-TRIONS Russian patent published in 2017 - IPC C07D487/10

Abstract RU 2635105 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to a process for the preparation of new 4-aryl-2,7,9-triazaspiro[4.5]decane-6,8,10-trions of general formula I, which can be used as potential sedatives, antidepressant or nootropic agents. In the general formula I

R=CH₃, R¹=H (Ia); R=CH₃, R¹=CH₃O (Ib); R=CH₃, R¹=(CH₃)₂N (Ic); R=CH₃, R¹=Cl (Id); R=C₆H₅, R¹=H (Ie); R=C₆H₅, R¹=CH₃O (If); R=C₆H₅, R¹=(CH₃)₂N (Ig); R=C₆H₅, R¹=Cl (Ih). The method is based on a three-component heterocyclization reaction and consists in mixing equimolar amounts of 5-(arylmethylene) hexahydropyrimidine-2,4,6-trions, N-methylglycine or N-phenylglycine and formaldehyde in dried toluene, followed by boiling of the reaction mixture for 17 hours.

EFFECT: improved properties of compounds.

12 ex

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RU 2 635 105 C1

Authors

Tyrkov Aleksej Georgievich

Yurtaeva Ekaterina Alekseevna

Dates

2017-11-09—Published

2016-07-15—Filed