METHOD FOR SYNTHESIS OF SULPHONE DERIVATIVES OF 2-NITRO-2-(3-ARYL-1,2,4-OXADIAZOL-5-YL)ETHANE Russian patent published in 2010 - IPC C07D271/06 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of novel sulphone derivatives of 2-nitro-2-(3-aryl-1,2,4-oxadiazol-5-yl)ethane of general formula I, which can be used as potential antimicobacterial preparations Ia-g, where la R-3-NO₂C₆H₄, R¹=NO₂, R²=H; b R=3-NO₂C₆H₄ R¹=NO₂, R²=CH₃; c R=4-CH₃OC₆H₄, R¹=NO₂, R²=H; d R=4-CH₃OC₆H₄, R¹=NO₂, R¹=CH₃; e R=4-CH₃OC₆H₄ R¹=CO₂Et, R²=H; f R=4-CH₃OC₆H₄, R¹=CO₂Et, R²=CH₃; g R=4-CH₃C₆H₄, R¹=CO₂Et, R²=H. The method involves heating and mixing substituted 2-nitro1-chloro-2-(3-aryl-1,2,4-oxadiazol-5-yl)ethane with an equimolar amount of sodium 4-tolysulphinate in a solvent and then holding the reaction mixture at room temperature.

EFFECT: method avoids solvent preparation and increases output of the desired product.

1 cl, 2 tbl, 7 ex