FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. Invention represents a genetic construct carrying codon-optimized composition, GC-composition, presence of polyA sections and a structure of mRNA-generated gene of consensual glycoprotein (protein G) of rabies virus. It has been shown that blood serums of mice, single immunized with such genetic structure, 21 days after vaccination showed anti-rabies virus neutralizing activity > 0.5 IU/ml.
EFFECT: disclosed is a genetic construct based on an optimized gene of rabies virus consensus glycoprotein for preventing rabies.
1 cl, 1 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| GENETIC (RECOMBINANT) DNA CONSTRUCT COMPRISING CODON-OPTIMIZED GLYCOPROTEIN GENE (PROTEIN G) OF RABIES VIRUS WITH CONSENSUS AMINO ACID SEQUENCE WHICH TAKES INTO ACCOUNT THE AMINO ACID SEQUENCE OF PROTEIN G, ISOLATED FROM RABIES VIRUS STRAIN CIRCULATING IN THE RUSSIAN FEDERATION | 2015 |
|
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|
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| ANTIRABIC INACTIVATED EMULSION CULTURE VACCINE FOR PROPHYLACTIC IMMUNIZATION OF DOMESTIC CARNIVORES AND FARM ANIMALS | 2019 |
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| METHOD OF OBTAINING PERORAL VACCINE AGAINST RABIES VIRUS | 2010 |
|
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| METHOD FOR RABIES VACCINE IMMUNOGENICITY DETERMINATION | 2016 |
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| TRIMERISED SINGLE-DOMAIN ANTIBODY THAT SPECIFICALLY BINDS WITH GLYCOPROTEIN G OF RABIES VIRUS, NEUTRALISING RABIES VIRUS | 2013 |
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| NEUTRALIZING MONOCLONAL ANTIBODY BINDING TO RABIES VIRUS GLYCOPROTEIN G, DNA FRAGMENTS CODING SAID ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2017 |
|
RU2718835C2 |
| RABIES VACCINE | 2014 |
|
RU2712743C2 |
| HUMANISED ANTIGEN-BINDING FRAGMENTS (Fab) AGAINST RABIES VIRUS, ISOLATED DNA FRAGMENT, CODING Fab AGAINST RABIES VIRUS, YEAST CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING Fab AGAINST RABIES VIRUS WITH APPLICATION OF YEASTS | 2010 |
|
RU2440412C2 |
