CYSTATHIONINE-γ-LYASE (CSE) INHIBITORS Russian patent published in 2018 - IPC C07D257/04 A61K31/41 A61P25/00 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula (I) and formula (IV) or pharmaceutically acceptable salts thereof, which inhibit cystathionine -γ-lyase (CSE). In a compound of formula (I) having the structure R₁ is H or unsubstituted C₁-C₆alkyl and A is selected from and -CONHSO₂R₄, where R₄ is independently unsubstituted C₁-C₆alkyl or unsubstituted phenyl. In a compound of formula (IV) having the above structure A means and R₁ is an optionally substituted or unsubstituted C₂-C₆alkyl, where C₂-C₆alkyl is independently optionally substituted with one or more additional groups independently selected from phenyl, C₁-C₄alkoxy, C₁-C₄alkylthio, halo-C₁-C₄alkyl, halo-C₁-C₄alkoxy, fluoro-C₁-C₄alkylamino, C₁-C₄alkylamino, di(C₁-C₄alkyl)amino.

EFFECT: compounds can be used to treat or prevent or reduce the incidence of a condition selected from nociceptive pain, acute postoperative pain, neuropathic pain, neuralgia of the trigeminal nerve (trigeminal neuralgia), diabetic peripheral neuropathy, herpetic neuralgia, postherpetic neuralgia, inflammatory pain, mixed neuropathic and inflammatory pain, rheumatoid arthritis, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, acute pancreatitis, chronic pancreatitis, pain associated with acute pancreatitis, pain associated with chronic pancreatitis, migraine, gout, ankylosing spondylitis, systemic lupus erythematosus (SLE), system inflammatory response syndrome (SIRS), multi-organ dysfunction syndrome (MODS), asthma, chronic obstructive pulmonary disease (COPD), sensitive skin, acne, rosacea (redheads), contact dermatitis and pain associated with cancer.

11 cl, 10 dwg, 1 tbl, 43 ex