IMIDAZOPYRIDAZINES Russian patent published in 2018 - IPC C07D487/04 A61K31/5025 A61P29/00 A61P19/02 A61P17/06 A61P3/10 A61P37/00 A61P11/06 A61P25/28 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, particularly to a heterocyclic compound of formula I or a pharmaceutically acceptable salt thereof, wherein A is pyridyl substituted with one or two A'; each A' is independently C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, pyrrolidinyl, piperidinyl optionally substituted with one or two C1-6 alkyls; n is 0 or 1; B is phenyl; each R is independently -C(=O)R¹, -C(=O)OR¹ or -C(=O)NHR¹; R¹ is H or R^1'; R^1' is C1-6 alkyl, phenyl, indolyl, indazolyl, pyridinyl C1-6 alkyl or morpholinyl optionally substituted with one or two ; each is hydroxy, C1-6 alkyl, C1-6 alkoxy, carboxy or oxo. Specific derivatives of imidazo[1,2-b]pyridazine are also described.

I.

EFFECT: technical result is obtaining novel heterocyclic compounds useful as inhibitors of SYK.

8 cl, 1 tbl, 96 ex