IMPROVED IMMUNOASSAY METHODS Russian patent published in 2018 - IPC G01N33/53 

Abstract RU 2662555 C2

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and can be used to diagnose cancer by determining the antibody production profile in a test sample containing the body fluid of a mammalian subject. For this purpose, the test sample is brought into contact with a plurality of different amounts of the antigen specific for the antibody. Specific binding amount of the antibody and antigen is then determined. Graph is plotted or the curve of dependence of the specific binding amount on the amount of antigen is plotted to construct the antibody production profile in said subject prior to the onset of the disease or throughout the course of the disease. In this case, the antibody is a biological marker of a disease state or a liability to disease where the antigen is MUC1, c-myc, EGFR, p53, ras, BRCA1, BRCA2, APC, HER2, PSA, CEA, CA19.9, NY-ESO-1, antigen 4-5, CAGE, PSMA, PSCA, EpCam, cytokeratin, recoverin, kallikrein, annexin, AFP, GRP78, CA125, mammaglobin or raf. Application for the diagnosis of cancer in a patient has also been proposed.

EFFECT: group of inventions makes it possible to diagnose a cancer in a patient by determining the profile of the production of an antibody in the test sample.

6 cl, 6 tbl, 15 dwg, 7 ex

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RU 2 662 555 C2

Authors

Robertson Dzhon Forsit Rassell

Barns Toni

Myurrej Andrea

Chepmen Kerolajn

Dates

2018-07-26Published

2010-12-01Filed