ANTIBODY ANALYSIS Russian patent published in 2022 - IPC G01N33/574 G01N33/543 

FIELD: medicine.

SUBSTANCE: group of inventions can be used for diagnosing liver cancer. Disclosed is a method for diagnosing liver cancer in a mammal by detecting an autoantibody immunologically specific for a tumor marker protein, selected from the group consisting of MMP9, AIF1, EpCAM and CDKN1B, in a test sample containing physiological fluid from a mammalian subject. Method comprises the steps of bringing a test sample into contact with a tumor marker antigen, selected from the group consisting of MMP9, AIF1, EpCAM and CDKN1B, and determining the presence or absence of tumor marker antigen complexes associated with autoantibodies present in the test sample, wherein the presence of said complexes is an indicator of the presence of liver cancer. Also disclosed is a method for determining an in vitro profile of antibodies of an individual suffering from liver cancer, a method for predicting a response to treatment against liver cancer, use of a tumor marker antigen in a method for detecting liver cancer and a kit for detecting liver cancer.

EFFECT: provides effective and non-invasive screening of liver cancer.

36 cl, 2 dwg, 31 tbl, 6 ex