FIELD: pharmaceuticals.
SUBSTANCE: group of inventions relates to chemical-pharmaceutical industry and includes pharmaceutical compositions and their use for modulating the activity of glutaminyl cyclase, for treatment of a disorder associated with the activity of glutaminyl cyclase, as well as for the prevention and/or treatment of a disorder associated with the aberrant activity of immune system cells, comprising a therapeutically effective amount of a compound of the formula: 
or pharmaceutically acceptable salt, hydrate or solvate thereof, and at least one pharmaceutically acceptable excipient.
EFFECT: group of inventions allows to obtain an effective glutaminyl cyclase modulator characterized by high inhibitory activity and efficacy in the therapy of diseases associated with the aberrant activity of immune system cells.
27 cl, 1 dwg, 10 tbl, 2 ex
| Title |
Year |
Author |
Number |
| NEW GLUTAMINE CYCLASE INHIBITOR AND ITS APPLICATION |
2018 |
- Nebolsin Vladimir Evgenevich
- Kromova Tatyana Aleksandrovna
- Rydlovskaya Anastasiya Vladimirovna
|
RU2791703C2 |
| NEW INHIBITOR OF GLUTAMINYL CYCLASE AND ITS USE |
2017 |
- Nebolsin Vladimir Evgenevich
- Kromova Tatyana Aleksandrovna
- Rydlovskaya Anastasiya Vladimirovna
|
RU2665633C1 |
| COMPOSITION FOR PROPHYLAXIS OR TREATMENT OF ALLERGIC DISEASE USING BLACK RICE EXTRACT AND ITS THERAPEUTIC APPLICATION |
2004 |
|
RU2313347C2 |
| NEW ZINC COMPLEX, ITS PREPARATION AND APPLICATION FOR THERAPY OF HUMAN AND ANIMAL DISEASES |
2018 |
- Nebolsin Vladimir Evgenevich
|
RU2697580C1 |
| PHARMACEUTICAL COMPOSITION, CONTAINING N-ACYL DERIVATIVES OF AMINO ACIDS, AND THEIR APPLICATION AS ANTI-ALLERGIC, ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY MEDICATIONS |
2008 |
- Nebol'Sin Vladimir Evgen'Evich
- Kromova Tat'Jana Aleksandrovna
- Zheltukhina Galina Aleksandrovna
- Kovaleva Violetta Leonidovna
|
RU2406727C2 |
| PHARMACEUTICAL COMPOSITION, CONTAINING DERIVATIVES OF GLUTARIMIDES, AND THEIR APPLICATION FOR TREATMENT OF EOSINOPHILIC DISEASES |
2013 |
- Nebol'Sin Vladimir Evgen'Evich
- Kromova Tat'Jana Aleksandrovna
- Rydlovskaja Anastasija Vladimirovna
- Chuchalin Aleksandr Grigor'Evich
|
RU2552929C1 |
| NEW COMPOUND ISOLATED FROM PSEUDOLYSIMACHION ROTUNDUM VAR. SUBINTEGRUM, WITH A HIGH CONTENT OF ACTIVE INGREDIENT, COMPOSITION CONTAINING SAID COMPOUND FOR PREVENTING OR TREATING ALLERGIC DISEASE, INFLAMMATORY DISEASE, ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND USE THEREOF |
2015 |
- Li Ennam
- Yu Chi-Sok
- Sin Te-Khi
- Yu Pen-Khvan
- O Si-Yan
- An Ken-Sop
- Li Khen-Ke
- Li Su Uj
- Son Khek-Khvan
- Sin In-Sik
- Yu Khen Von
|
RU2685732C2 |
| COMPOSITION FOR ASTHMA PREVENTION OR TREATMENT CONTAINING MONOACETHYLDIACYL GLYCERINE COMPOUND AS ACTIVE INGREDIENT |
2014 |
- O Sej-Ryan
- An Kyun Sop
- Li Su Ui
- Sin In Sik
- Sin Na-Ne
- Li Te-Sok
- Kan Chonko
- Chon Yun-Sik
- Khan En-Khe
- Son Ki En
|
RU2636615C2 |
| PHARMACEUTICAL COMPOSITION EXHIBITING ANTI-INFLAMMATORY, PARTICULARLY ANTIASTHMATIC ACTION, APPLICATIONS OF PHARMACEUTICAL COMPOSITION (VERSIONS) AND DRUG (VERSIONS) |
2008 |
- Demin Aleksandr Viktorovich
- Mart'Janov Vitalij Afanas'Evich
- Shuster Aleksandr Mikhajlovich
|
RU2406498C2 |
| NOVEL TACHYKININ RECEPTOR ANTAGONIST AND USE THEREOF |
2018 |
- Nebolsin Vladimir Evgenevich
|
RU2697414C1 |
