FIELD: chemistry.
SUBSTANCE: disclosed inventions relate, in particular, to the fused protein comprising variant of the nucleoprotein antigen from the strain of influenza A virus, containing the E339A and R416A point mutations fused with the chicken C4bp oligomerization domain variant, in particular, IMX313T and IMX313P. Inventions also relate to the fused protein encoding nucleic acid; containing the said nucleic acid vector; immunogenic composition, which can be used as the vaccine or for the immunotherapy for the purpose of influenza diseases prevention, which contains the presented fused protein.
EFFECT: inventions allow to improve the influenza A virus NP antigen immunogenicity and can be used in the medical industry.
14 cl, 20 dwg, 3 tbl, 11 ex
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