FIELD: genetic engineering, immunology, molecular biology, pharmacy. SUBSTANCE: DNA structures involve genes encoding human influenza virus proteins: nucleoprotein, hemaglutinin, matrix protein. Vector V1Jns is used as structure base involving cytomegalovirus promoter with intron A sequence, transcription termination region of bovine growth hormone with fused unique site Sfi I, region of replication onset and kanamycin resistance gene. In administration in subject tissues DNA structures as components of immunogenic composition or vaccine express gene products of influenza virus that can provide immune protection from infection with homologous or heterogeneous strains of influenza virus. Invention ensures to provide a long time acting cross-reactive immunity against influenza virus and can be used in preparing pharmaceutical preparations providing immune protection against influenza virus. EFFECT: improved method of induction and vaccination, valuable medicinal properties. 8 cl, 51 dwg, 7 tbl, 15 ex
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