FIELD: biotechnology.
SUBSTANCE: described is an outer membrane vesicle (OMV) from a gram-negative bacterium, where the OMV comprises at least one heterologous protein that is free in the lumen of the OMV, and where the OMV elicits an immune response to the heterologous protein when administered to a mammal, where the heterologous protein is functionally active in the OMV lumen.
EFFECT: invention also provides methods for preparing OMVs of the invention, pharmaceutical compositions comprising the OMVs of the invention, especially immunogenic compositions and vaccines, and methods of generating an antibody immune response in a mammal using OMVs.
35 cl, 16 dwg, 1 tbl, 12 ex
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