IMMUNOGENIC COMPOSITION FOR NEISSERIA MENINGITIDIS (OPTIONS) Russian patent published in 2018 - IPC A61K39/95 C07K14/22 C07K16/12 A61P31/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to immunology. Proposed are immunogenic compositions for inducing an immune response against Neisseria meningitidis stain of subfamily A of serogroup B and against Neisseria meningitidis stain of subfamily B of serogroup B in a human. Composition comprises an effective amount of the first N-terminally lipidated polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, and the second N-terminally lipidated polypeptide including the amino acid sequence set forth in SEQ ID NO: 2. In one embodiment, the composition may be administered simultaneously with an immunogenic composition against human papillomavirus. In another embodiment, the composition may be administered simultaneously with an immunogenic composition against diphtheria, tetanus, pertussis and poliomyelitis. Robust immune responses against human papillomavirus, diphtheria, tetanus, pertussis and poliomyelitis were generated after concomitant administration of the composition without negatively affecting the bactericidal response against N. meningitidis.

EFFECT: immunogenic composition for Neisseria meningitidis is proposed.

4 cl, 2 dwg, 9 tbl, 10 ex