FIELD: organic chemistry.
SUBSTANCE: invention relates to nanocrystals of polymorph 1 of fluticasone propionate having a crystalline form (Form A), the crystallographic axis of which is substantially perpendicular to the surfaces that determine the thickness of the nanocrystals, nanocrystals have a size distribution of about 100-1000 nm and are characterised by a powder X-ray diffraction pattern including characteristic peaks at approximately 7.8, 15.7, 20.8, 23.7, 24.5 and 32.5 2θ degrees and additional peaks at approximately 9.9, 13.0, 14.6, 16.0, 16.9, 18.1 and 34.3 2θ degrees, and further characterised by a melting point of 299.5°C with a melting interval of 10°C. Invention also relates to topical formulations, a process for the preparation of fluticasone propionate nanocrystals.
EFFECT: technical result: chemically stable nanocrystals of polymorph 1 of fluticasone propionate, having high purity were obtained.
14 cl, 39 dwg, 43 tbl, 12 ex
