METHOD OF ORGAN-PRESERVING TREATMENT OF LOCALIZED BREAST CANCER Russian patent published in 2018 - IPC A61N5/10 A61B6/03 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology and radiation therapy, and can be used for organ-preserving treatment of localized breast cancer (BC). Use contact radiation therapy using the 3D-visualization method. Value of the boost dose is calculated taking into account the degree of differentiation and luminal tumor subtype. Thus, the dose per fraction is 8.5 Gy for the A luminal subtype and the degree of G1 differentiation of the tumor. Dose per fraction is 10 Gy for the A luminal subtype and the degree of G2 differentiation of the tumor. Dose per fraction is 12 Gy for the B luminar subtype and any degree of differentiation of the tumor. Formulate the calculated dose on the tumor bed, taking into account the tumor length in each of the conditional axes of the three-dimensional coordinate system: establish one radiation source for every 0.5 mm of tumor tissue, which is complemented by the installation of two sources, taking into account the capture of healthy tissue, regardless of the size of the tumor.

EFFECT: method provides reduction in the risk of radiation reactions and damage in the organ-preserving treatment of patients with localized breast cancer (T1–T2), distribution of radioactive sources in the tumor bed in accordance with the volume of the affected tissue, prevention of local recurrence due to calculation the magnitude of the boost dose and number of radioactive sources.

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