METHOD FOR DIFFERENTIATED TREATMENT OF PATIENTS WITH LOCALIZED BREAST CANCER Russian patent published in 2017 - IPC A61N5/10 A61K51/00 A61P35/00 A61B6/00 A61B17/00 

FIELD: medicine.

SUBSTANCE: 6 cycles of neoadjuvant polychemotherapy (NAPCT) under the control of mammotsmintigraphy (MSG) with 99 mTc-technetril are performed and, in case of a complete MSG response of the primary tumour, additional conformal remote irradiation is performed on the entire mammary gland in a total focal dose of 50 Gy and interstitial brachytherapy with high dose rate to the area of primary tumour localization in the form of three fractions of 4 Gy without surgical removal of the tumour. The complete MSG response of the primary tumour is judged after the 3rd cycle of NAPCT, then continuing 3 more cycles of NAPCT. In other cases - in the absence of a complete MCG response - after the end of the 6th NAPCT cycle, surgical treatment is performed followed by postoperative irradiation in a total dose of 50 Gy.

EFFECT: non-invasive, non-traumatic choice of treatment, high accuracy of selection of patients with complete tumour response to drug treatment for subsequent irradiation without surgery, provides an increase in the non-surgical treatment effectiveness.

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