ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF Russian patent published in 2018 - IPC C07C251/86 C07D271/107 C07D233/64 C07D333/42 A61K31/166 A61K31/4164 A61K31/381 A61K31/4245 A61P35/02 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds having structural formula I in which ring B is a substituent selected from the group consisting of 3-OCH₂CH₃-4-OH-phenyl and 2-OH-4-Br-phenyl, as well as the use of said compounds, in which ring B is a substituent selected from the group consisting of phenyl, 4-Br-phenyl, 4-NO₂-phenyl, 3-OCH₃-phenyl, 1-naphthyl, 2-naphthyl, 4-Cl-phenyl, 3-OCH₂CH₃-4-OH-phenyl and 2-OH-4-Br-phenyl, in the treatment of cancer. Invention also relates to the use of specific compounds of formulae Ia and IIa in the treatment of a disease associated with cell proliferation. Mechanism of action of the most active compounds was determined using DNA microarrays and subsequent tests indicated by a chip, as well as in selectivity tests in healthy human lymphocytes.

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EFFECT: invention also relates to pharmaceutical compositions containing said compounds for the treatment of a disease associated with cell proliferation, wherein the disease is selected from acute lymphoblastic leukemia (ALL), tumours and inflammation.

8 cl, 5 dwg, 8 tbl, 8 ex