CONJUGATE, MEDICATION AND METHODS OF TREATMENT AND/OR PREVENTION OF DEPRESSION AND DISEASE ASSOCIATED WITH LEWY BODIES CONCRETION Russian patent published in 2018 - IPC A61K31/135 A61K31/7088 A61P25/16 A61P25/24 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and refers to a conjugate comprising at least one selectivity agent specifically binding to at least one neurotransmitter transporter and selected from the group consisting of a selective serotonin reuptake inhibitor (SSRI), a noradrenaline reuptake inhibitor (NRI), a norepinephrine and dopamine reuptake inhibitor (NDRI), and a serotonin, norepinephrine and dopamine reuptake inhibitor (SNDRI), and at least one nucleic acid adapted to specifically bind to a target molecule expressed in a cell in which the neurotransmitter transporter is expressed. Group of inventions also relates to the use of said conjugate in the treatment and / or prevention of a disorder associated with depression, in the treatment and / or prevention of a disease associated with the deposition of Lewy bodies.

EFFECT: group of inventions ensures the start of internalisation of the nucleic acids of the claimed conjugates in cells expressing the neurotransmitter transporters with which they interact.

18 cl, 42 dwg, 2 tbl, 13 ex