FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns complex based on micro-bubbles for therapeutic agent delivery to target tissue containing micro-bubble with outer shell containing mixture of native and denatured albumin and hollow core, encapsulating gas perfluorocarbon; therapeutic agent; bifunctional linker. Group of inventions also concerns method of delivering above complex based on micro-bubbles to target tissue.
EFFECT: group of inventions provides increased binding of therapeutic agents with micro-bubbles to minimize non-targeted delivery of said agent.
17 cl, 4 ex, 10 dwg, 3 tbl
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