METHOD OF COMBINED TREATMENT OF PATIENTS WITH PRIMARILY OPERABLE AND LOCALLY ADVANCED INOPERABLE BREAST CANCER Russian patent published in 2018 - IPC A61B18/04 A61N7/02 A61K31/337 A61K31/675 A61K31/704 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, oncology, and can be used for combined treatment of patients with primarily operable or locally advanced inoperable breast cancer. To do this, drug therapy, including courses of neoadjuvant combined polychemotherapy (NAPCP) according to the 4AC→4T scheme: doxorubicin 60 mg/m² + cyclophosphamide 600 mg/m² every 3 weeks, followed by 12 injections of paclitaxel 80 mg/m² weekly. Simultaneously with the drug therapy, 8 courses of high-intensity focused ultrasound therapy (VFUZT) with an average acoustic power of 300–600 W daily, with a break of 3 weeks. With a maximum tumor size of up to 30 mm, 3 sessions of VFVTT for 1 course are carried out. With a maximum tumor size of 31–40 mm – 4 sessions per 1 course. With a maximum tumor size of more than 40 mm – 5 sessions per 1 course.

EFFECT: method provides increase in effectiveness of NAPHT, maximum reduction in the volume of the tumor, while minimizing the risk of side effects – skin burns of I-II degree, development of high-intensity pain syndrome in treatment zone, translation of the locally advanced process into a localized one with the possibility of performing the next stage of treatment – radical surgery in a minimal amount.

1 cl, 2 ex