METHOD OF REDUCTION OF THE EXPRESSION OF CHRONIC PAIN SYNDROME IN PATIENTS WITH PANCREATIC CANCER WITH FUNCTIONAL STATUS ECOG 0-2 POINTS Russian patent published in 2023 - IPC A61N7/00 A61K31/7068 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to oncology, in particular to methods of palliative care for patients with malignant neoplasms of the abdominal cavity and retroperitoneal space, suffering from chronic abdominal pain syndrome. The invention relates to medicine, namely to oncology, and can be used to reduce the severity of chronic pain in patients with pancreatic cancer. The method involves conducting courses of monochemotherapy with gemcitabine at a dosage of 750–1,000 mg/m² IV on the 1st, 8th, 15th days every 4 weeks in combination with HIFU therapy. HIFU-therapy sessions are carried out daily, except for the days of administration of the chemotherapy drug on a low-energy device with an ultrasonic flow intensity of 2 kW/cm², the number of pulses per point is 200, the pulse duration is 200 ms, the pause duration is 50 ms, the distance between the points along the axes x/y/z = 3/3/7 mm. If the tumor size is up to 2.0 cm, for one course of HIFU therapy, 4 sessions are performed with an exposure duration of up to 30 minutes, or 3 sessions are performed from 31 to 45 minutes, or 2 sessions are performed from 46 to 60 minutes. If the tumor size is from 2.1 to 4.0 cm, then for one course of HIFU therapy, 5 sessions are performed with an exposure duration of up to 30 minutes, or 4 sessions are performed from 31 to 45 minutes, or 3 sessions are performed from 46 to 60 minutes. If the tumor size is from 4.1 to 6.0 cm, then for one course of HIFU therapy, 6 sessions are performed with an exposure duration of up to 30 minutes, or 5 sessions are performed from 31 to 45 minutes, or 4 sessions are performed from 46 to 60 minutes. If the tumor size is from 6.1 to 8.0 cm, then for one course of HIFU therapy, 7 sessions are performed with an exposure duration of up to 30 minutes, or 6 sessions are performed from 31 to 45 minutes, or 5 sessions are performed from 46 to 60 minutes. If the tumor size is more than 8.0 cm, then for one course of HIFU therapy, 8 sessions are performed with an exposure duration of up to 30 minutes, or 7 sessions are performed from 31 to 45 minutes, or 6 sessions are performed from 46 to 60 minutes.

EFFECT: use of the invention makes it possible to increase the frequency of pain syndrome control after 6 months of combined therapy, by achieving stabilization and/or partial response of the primary focus, a low degree of cytostatic toxicity and the absence of a negative effect of treatment on the functional status of patients.

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