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2 288 710

(13)

(51)

IPC

A61K31/196(2006-01-01)

A61K31/513(2006-01-01)

A61K31/675(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2004129377/14, 2004-10-05

(24)

Start date

2004-10-05

(22)

Actual filing date

2004-10-05

(45)

Published

2006-12-10

(72)

Inventor

Slonimskaja Elena MikhajlovnaKrasulina Natal'Ja Anatol'EvnaDoroshenko Artem Vasil'EvichKokorina Julija LeonidovnaGarbukov Evgenij Jur'Evich

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Onkologii Tomskogo Nauchnogo Tsentra Sibirskogo Otdelenija Rossijskoj Akademii Meditsinskikh Nauk Gu Nii Onkologii Tnts So Ramn

METHOD OF TREATING PATIENTS WITH OPERABLE MAMMARY GLAND CANCER Russian patent published in 2006 - IPC A61K31/196 A61K31/513 A61K31/675 A61P35/00

Abstract RU 2288710 C2

FIELD: oncology.

SUBSTANCE: treatment consists in performing 2-4 courses of preoperative chemotherapy with 2-weak intervals between courses, each course comprising intravenous administration of methotrexate in dose 40 mg/m² on first or eighth day and intramuscular cyclophosphanin dose 100 mg/m² during 14 days, while introducing additionally oral Xeloda in dose 1000 mg/m² twice a day on the first to fourteenth days.

EFFECT: achieved complete regression of tumor focus owing to high selectivity of Xeloda preparation diminishing toxic effect of chemotherapy.

3 ex

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RU 2 288 710 C2

Authors

Slonimskaja Elena Mikhajlovna

Krasulina Natal'Ja Anatol'Evna

Doroshenko Artem Vasil'Evich

Kokorina Julija Leonidovna

Garbukov Evgenij Jur'Evich

Dates

2006-12-10—Published

2004-10-05—Filed