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2 664 661

(13)

(51)

IPC

C07C45/68(2006-01-01)

C07C49/607(2006-01-01)

(21) (22)

Application

2016100787, 2016-01-12

(24)

Start date

2016-01-12

(22)

Actual filing date

2016-01-12

(45)

Published

2018-08-21

(72)

Inventor

Khafizova Lejla OsmanovnaShajbakova Mariya GennadevnaChobanov Nuri MamedeevichDzhemilev Usein Memetovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Neftekhimii I Kataliza Rossijskoj Akademii Nauk

2,3-DIALKYL-2-CYCLOOCTENE-1-ONE PREPARATION PROCESS Russian patent published in 2018 - IPC C07C45/68 C07C49/607

Abstract RU 2664661 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a process for the preparation of 2,3-dialkyl-2-cycloocten-1-ones of general formula : , which are used as initial synthons for the creation of biologically active compounds, exhibiting antiviral, antifungal and antitumor properties. Process is characterized in that dialkylacetylenes of general formula R-C≡C-R, where R=C₃H₇ or C₄H₉, are reacted with a double excess of adipic acid methyl ester CH₃CO₂(CH₂)₄CO₂CH₃ and EtAlCl₂ in the presence of magnesium (Mg, powder) and catalyst Cp₂TiCl₂, the reaction is carried out at a molar ratio RC≡CR : CH₃CO₂(CH₂)₄CO₂CH₃ : EtAlCl₂ : Mg : Cp₂TiCl₂=10:20:(40-60):(40-60):(1.8-2.2), in tetrahydrofuran under argon at 60°C and atmospheric pressure for 4-8 hours.

EFFECT: proposed method allows to obtain the target product with a yield of 59 to 83%.

1 cl, 1 tbl, 10 ex

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RU 2 664 661 C2

Authors

Khafizova Lejla Osmanovna

Shajbakova Mariya Gennadevna

Chobanov Nuri Mamedeevich

Dzhemilev Usein Memetovich

Dates

2018-08-21—Published

2016-01-12—Filed