METHOD OF OBTAINING TETRAALKYL-SUBSTITUTED FURANS Russian patent published in 2014 - IPC C07D307/06 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining tetraalkyl-substituted furans of general formula (1) , where R=C₂H₅, C₃H₇, C₄H₉; R'=CH₃, C₃H_7, characterised by the fact that dialkylacetylene of general formula R-C≡C-R, where R=C₂H₅, C₃H₇, C₄H₉, is subjected to interaction with a double excess of ester of general formula R'CO₂R", where R'=CH₃, C₃H₇;R"=C₂H₅, C₅H₁₁, and ethylaluminiumdichloride (EtAlCl₂) in the presence of magnesium (Mg, powder) and a catalyst Cp₂TiCl₂ in a molar ratio of RC≡CR:R'CO₂R":EtAlCl₂:Mg:Cp₂TiCl₂=10:20:(20-30):(10-14):(0.8-1.2), in tetrahydrofuran in argon atmosphere at 60°C and under atmospheric pressure for 4-8 h. The said compounds are of interest as initial synthons for the creation of biologically active compounds of the medicinal and agricultural purpose, demonstrating antibacterial, antiviral, anti-inflammatory, antifungal, anti-tumour, painkilling, anticonvulsant properties.

EFFECT: method makes it possible to obtain tetraalkylsubstituted furans with the high output.

1 tbl, 1 ex