METHOD FOR METHYL n-[3,4-DIALKYL-5-(n-METHOXY-n-OXOALKYL)-2-FURYL] ALKANOATES PRODUCTION Russian patent published in 2017 - IPC C07D307/40 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for methyl n-[3,4-dialkyl-5-(n-methoxy-n-oxoalkyl)-2-furyl]alkanoates production by the general formula where R = C₂H₅, C₃H₇, C₄H₉; R'=(CH₂)_nCOOCH₃, n=5, 6, by reaction of dialkyl acetylenes of the general formula R-C≡C-R, where R=C₂H₅, C₃H₇, C₄H₉, with carboxylic acid esters in the presence of magnesium (Mg, powder) and Cp₂TiCl₂ catalyst with methyl esters α,ω-dicarboxylic acids CH₃CO₂(CH₂)_nCO₂CH₃, where n=5, 6, at the molar ratio of RC≡CR : CH₃CO₂(CH₂)_nCO₂CH₃:EtAlCl₂ : Mg:Cp₂TiCl₂ = 10:20(50-70):40:(1.8-2.2) in tetrahydrofuran under argon atmosphere at 60°C and atmospheric pressure during 4-8. Methyl n-[3,4-dialkyl-5-(n-methoxy-n-oxoalkyl)-2-furyl]alkanoates (1) yield is 54-76%.

EFFECT: compound are important as initial synthons for biologically active compounds creation for medical and agricultural purposes, exhibiting antibacterial, antiviral, anti-inflammatory, antifungal, antitumor, analgesic, anticonvulsant properties.

1 tbl, 1 ex