FIELD: chemistry.
SUBSTANCE: invention relates to an alkynyl indazole derivative having general formula (I): 
, or a pharmaceutically acceptable salt thereof. In formula (I), R1 is lower alkyl, X and Y are the same or different and each is CH or N, provided that X and Y are not simultaneously N, Z is a group having general formula (a):
(a), in which R2 is a lower alkyl group which may have a substituent selected from the group consisting of: hydroxy, amino, dimethylamino, acetylamino, or morpholino, n is an integer from 1 to 7, A is a substructure represented by the following formula: 
Medicament containing an alkynyl indazole derivative is also provided.
EFFECT: alkynyl indazole derivative of formula (I) is a VEGF receptor tyrosine kinase inhibitor and is useful in the treatment or prevention of retinal disease accompanying angiogenesis or edema.
7 cl, 6 tbl, 126 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 4-ARYL-HEXAHYDRO-7H-IMIDAZOLO[1,5-B][1,2]OXAZINE-7-ONES AND METHOD FOR PRODUCTION THEREOF | 2018 |
|
RU2670097C1 |
| SUBSTITUTED 2H-PYRAZOLE DERIVATIVE | 2016 |
|
RU2722363C2 |
| NOVEL COUMARIN DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | 2007 |
|
RU2428420C2 |
| GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE INGREDIENT | 2008 |
|
RU2450001C2 |
| SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE AGENT | 2014 |
|
RU2654483C2 |
| SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST, METHOD OF ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING IT AS AN ACTIVE INGREDIENT | 2020 |
|
RU2798605C1 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| AMINOTRIAZOLOPYRIDINES AND USING THEM AS KINASE INHIBITORS | 2009 |
|
RU2552642C2 |
| SUBSTITUTED BENZENE COMPOUNDS | 2013 |
|
RU2658919C2 |
| BENZIMIDAZOLE DERIVATIVES | 2020 |
|
RU2803284C1 |
