FIELD: medicine.
SUBSTANCE: invention can be used in medicine and relates to a single-stranded modified oligonucleotide consisting of 16–30 linked nucleosides and having a nucleotide sequence consisting of sequences SEQ ID NO: 226, 17, 50, 224, 722, 807, 1327, 1340 and 1379, wherein said oligonucleotide comprising: a gap segment consisting of linked deoxynucleosides; a 5’ wing segment consisting of linked nucleosides; and 3’ wing segment consisting of linked nucleosides; the gap segment is positioned between the 5’ wing segment and the 3’ wing segment; wherein each nucleoside of each wing segment comprises a 2’-O-methoxyethyl sugar or a constrained ethyl sugar; each internucleoside linkage is a phosphorothioate linkage; each cytosine is 5-methylcytosine.
EFFECT: proposed is a novel modified oligonucleotides and compositions based thereon, effective for the treatment of HBV-related disease, disorder or condition.
16 cl, 22 ex, 77 tbl, list of sequences
| Title | Year | Author | Number |
|---|---|---|---|
| MODULATION OF ANDROGEN RECEPTOR EXPRESSION | 2013 |
|
RU2670486C9 |
| COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF DYSTROPHIC MIOTONIN-PROTEINKINASE (DMPK) | 2014 |
|
RU2690333C2 |
| COMPOSITIONS FOR MODULATING EXPRESSION OF SOD-1 | 2015 |
|
RU2704619C2 |
| MODULATION OF EXPRESSION OF TRANSTHYRETIN | 2011 |
|
RU2592669C2 |
| COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION | 2014 |
|
RU2670614C9 |
| MODULATING EXPRESSION OF ANGIOPOIETIN-LIKE PROTEIN 3 | 2014 |
|
RU2706964C2 |
| COMPOSITIONS AND METHODS FOR MODULATING EXPRESSION OF APOLIPOPROTEIN (A) | 2014 |
|
RU2824214C1 |
| FACTOR 11 EXPRESSION MODULATION | 2009 |
|
RU2535964C2 |
| CONJUGATED ANTISENSE COMPOUNDS AND USE THEREOF | 2014 |
|
RU2697152C2 |
| MODULATORS OF COMPLEMENT FACTOR B | 2014 |
|
RU2662967C2 |
