FIELD: pharmaceuticals.
SUBSTANCE: invention relates to 3-guanidino-6-R-azolo[1,2,4,5]tetrazines of formula Ia-d, wherein X=CH, R=H (Ia), X=CH, R = isopropylthio (Ib), X = N, R = isopropylthio (Ic), X = N, R = dodecylthio (Id) having an antiglycating activity. Invention also relates to process for their preparation.
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EFFECT: new compounds of formula Ia-d having antiglycating activity, which can be used for the prevention and treatment of late complications of diabetes mellitus and diseases caused by the accumulation in the body of products of non-enzymatic interaction of proteins with glucose.
2 cl, 2 tbl, 4 ex
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