PHTHALAZINE DERIVATIVES Russian patent published in 2018 - IPC C07D237/34 A61K31/502 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I

, in which R¹ is H, Hal or CH₃, X is Ar or Cyc, Ar is phenyl which is unsubstituted or mono-, di- or trisubstituted Hal, NO₂, CN, A and/or [C(R²)₂]_pOR², R² is H or A, Cuc means cycloalkyl which contains 3, 4, 5, 6 or 7 C-atoms, A stands for unbranched or branched alkyl, which contains 1–6 C-atoms, where 1–5 H atoms can be replaced by F, Hal is F, Cl, Br or I, p means 0, 1, 2, 3 or 4, n means 1, 2 or 3, and their pharmaceutically acceptable solvates, salts, including mixtures thereof in all ratios. Method for the preparation of compounds of formula I and medicaments are also provided.

EFFECT: compounds of formula I are inhibitors of the tankyrase and can be used to treat and/or prevent malignant neoplasm, multiple sclerosis, cardiovascular diseases, central nervous system lesions and various forms of inflammation.

6 cl, 2 tbl, 18 ex