DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY Russian patent published in 2018 - IPC A61K9/00 A61M37/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of implantable devices for controlled drug delivery. Drug delivery device comprises a body having a water-permeable wall bounding a reservoir defined within the body, wherein the body comprises an elastic portion; a drug formulation which comprises a drug and disposed within the reservoir, and at least one restraining plug closing off an opening of the body, the opening being in fluid communication with the reservoir. Water-permeable wall is configured to allow water to enter the drug delivery device and contact the water with the drug formulation in the reservoir. Said restraining plug contacts the elastic portion of the body and controls release of the drug from the device by the transient formation of one or more micro-channels between the elastic portion of the body and said restraining plug. Also disclosed is a method of administering a drug to a patient's body.

EFFECT: group of inventions reduces the risk of unexpected release of a drug during compression or deformation of the device.

25 cl, 21 dwg, 3 tbl, 5 ex