PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS Russian patent published in 2018 - IPC C07D451/02 A61K31/46 A61P11/00 A61P25/20 A61P25/22 A61P25/30 A61P25/34 

Abstract RU 2669701 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) wherein A is selected from substituted 3–12 membered cyclohydrocarbyl or heterocyclic hydrocarbyl or cyclic heterohydrocarbyl, wherein said heterocyclic hydrocarbyl or cyclic heterohydrocarbyl contains 1 or 2 heteroatoms in the ring, independently selected from N and S; B is selected from C(=O); X is a single bond; D and L are independently selected from CH2; T is C; M is selected from C(Y)(R1a), when Q is selected from C (R1b)(R1c), or M is selected from C(R1b)(R1c) when Q is selected from C(Y)(R1a); where A is selected from the structural unit shown in formula (A1) or (A2), the values of the remaining radicals are indicated in the claims. (I) (A1) (A2).

EFFECT: technical result: obtaining new compounds of formula (I), having the properties of orexin receptor antagonists.

8 cl, 1 tbl, 37 ex

Similar patents RU2669701C2

Title Year Author Number
REGULATORS OF DERIVATIVES OF STEROIDS, METHODS OF THEIR OBTAINING AND USE 2019
  • Su Yidong
  • Chen Xiaopo
  • Wang Jun
  • Bao Rudi
RU2803499C1
FIVE-MEMBERED HETEROCYCLIC PYRIDINE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF 2014
  • Shen Tszinkan
  • Gen Mejyuj
  • Din Tszyan
  • Syu Bin
  • Aj Tszin
  • Ma Yujchi
  • Van Syu
  • Pen Sya
  • Chen Yuelej
  • Chen Dantsi
  • Men Tao
  • Ma Lanpin
  • Tszi Inchun
RU2668074C2
THIENODIAZEPINE DERIVATIVES AND THEIR USE 2018
  • Shen, Chunli
  • U, Chende
  • Lyu, Yun
  • Gun, Chzhen
  • Li, Tszyan
  • Chen, Shukhuej
RU2795005C2
DERIVATIVE BASED ON DIHYDROPYRIMIDO-RING AS HBV INHIBITOR 2015
  • Khe Khajin
  • Chzhou Kaj
  • Tsin Khua
  • Li Syaolin
  • Chzhou Yuedun
  • Van Syaofej
  • Chi Syuemej
  • Li Tszyan
  • Chen Shukhuej
RU2693897C2
PYRIMIDINE DERIVATIVES AGAINST INFLUENZA VIRUS 2017
  • Syun, Tszian
  • Lun, Chaofen
  • Van, Tszintszin
  • Chen, Syaosin
  • Chen, Kevin Kh
  • Se, Chen
  • Li, Pen
  • Pen, Syuantszya
  • Li, Tszyan
  • Chen, Shukhuej
RU2727772C1
SUBSTITUTED INDOLE COMPOUNDS AS REDUCING REGULATORS OF ESTROGEN RECEPTORS 2017
  • Lu, Tszyanyu
  • Din, Charlz Z.
  • Khu, Likhun
  • Khe, Khuejtszyun
  • Chen, Shukhuej
  • Dun, Tszyatsyan
  • Van, Te-Lin
RU2722441C2
PYRIDINO[1,2-A]PYRIMIDONE ANALOGUE USED AS AN MTOR/PI3K INHIBITOR 2015
  • Guan Khojpin
  • U Chende
  • Yuj Tao
  • Khuan Lej
  • Khao Dunlin
  • Gao Bo
  • Sun Tszikuj
  • Shi Nenyan
  • Chen Shukhoj
RU2658912C1
DERIVATIVES OF PYRIDINE AND APPLICATION THEREOF AGAINST MICROBACTERIA 2015
  • Din Chzhaochzhun
  • Chen Shukhoj
  • Khuan Chzhigan
  • Lo Vej
  • Tsaj Chzhe
  • Van Epen
  • Tan Dundun
RU2664587C1
QUINOLINE COMPOUNDS, METHODS FOR PRODUCTION THEREOF AND USE THEREOF AS MEDICINAL AGENT WHICH INHIBITS URATE TRANSPORTER 2016
  • Fan, Lej
  • Du, Vu
  • Li, Sinkhaj
  • Chen, Yuanvej
  • Syuj, Kesin
  • Chen, Ke
  • Chzhan, Shaokhua
  • Luo, Tonchuan
RU2715229C2
BENZAMIDE DERIVATIVES HAVING ANTICANCER ACTIVITY, METHODS FOR PRODUCTION THEREOF AND USE THEREOF 2011
  • Baj Khua
  • Chzhao Sjujjan
  • Gun Junsjan
  • Chzhun Tszin'Tsin
  • Chzhu Tsifehn
  • Lju Sjaojuj
  • Lju Lifehj
  • Chzhou Tsisjan'
RU2565079C2

RU 2 669 701 C2

Authors

Khe Khajin

Vu Sunlyan

Chzhan Yan

Ma Byao

Chen Yuan

Van Yukhe

Chen Shukhuej

Lyuj Tsyan

Lan Tszon

Lyu Sin

Dates

2018-10-15Published

2015-02-27Filed