FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a quinoline derivative of formula (A) or a pharmaceutically acceptable salt thereof, wherein Z is selected from O or -NH-; W1 is N; W2 is CRb; W3 is CRc; R2 is selected from hydrogen and R3 is selected from methyl; or R2 is selected from hydrogen and R3 is selected from ethyl; or R2 is selected from hydrogen and R3 is selected from isopropyl; or R2 and R3 both are selected from methyl; or R2 and R3 both are selected from ethyl; or R2 and R3 both are selected from n-propyl; Rb is selected from a group comprising hydrogen, halogen, C1-C3-alkyl, C3-cycloalkyl, C6-aryl, heteroaryl selected from pyridine, where said alkyl, aryl or heteroaryl is independently and optionally substituted with one to three substitutes selected from a group comprising halogen, cyano, oxo, C1-alkyl, C1-halogenalkyl, -ORd; Rc is selected from a group comprising halogen, C1-C3-alkyl, C3-cycloalkyl, C6-aryl, heteroaryl selected from pyridine, where said alkyl, aryl or heteroaryl is independently and optionally substituted with one to three substitutes selected from a group comprising halogen, cyano, oxo, C1-alkyl, C1-halogenalkyl, -ORd; Rd is selected from a group comprising hydrogen, C1-C3-alkyl, C3-C4-cycloalkyl, where said alkyl is independently and optionally substituted with two to three substitutes, which are halogen; X, Y are hydrogen; when Z is O, R4 is hydrogen. Invention also relates to a method of producing a compound of formula (A) and use thereof.
EFFECT: obtaining a novel quinoline derivative which inhibits URAT1 and is useful in treating gout, recurrent gout, gouty arthritis, hyperuricemia.
9 cl, 2 tbl, 2 ex
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