PYRIMIDINE DERIVATIVES AGAINST INFLUENZA VIRUS Russian patent published in 2020 - IPC C07D471/04 C07D403/04 A61P31/16 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R₁ is selected from C_1-6 alkylthio, 5–6-member heteroaryl containing 1 or 2 heteroatoms, C_2-6-alkynyl, C_3-6 - cycloalkyl, each of which is optionally substituted with 1, 2 or 3 R; T₁ is selected from N or CH; T₂ is selected from N or C (R₂); R₂ is selected from H, F, Cl, Br, I; R₃ is selected from H, halogen or C_1-6-alkyl, each of which is optionally substituted with 1, 2 or 3 R depending on R₁, wherein the number of heteroatoms or heteroatomic groups is independently independently selected from 1 or 2. Invention also relates to individual compounds, isomers and stereoisomers thereof and pharmaceutically acceptable salts thereof, as well as to use thereof in preparing a medicament for treating diseases associated with influenza viruses.

EFFECT: technical result consists in obtaining compounds for preventing and treating epidemic influenza caused by influenza A virus, and epidemic influenza caused by highly pathogenic avian influenza viruses having high safety, good oral bioavailability.

21 cl, 8 tbl, 6 ex