METHOD OF INCREASING EFFECTIVENESS OF AUXILIARY REPRODUCTIVE TECHNOLOGIES IN PATIENTS WITH REPEATED NON-EFFECTIVE ATTEMPTS OF IMPLANTATION Russian patent published in 2018 - IPC A61B17/42 A61K31/565 A61K31/57 A61P15/08 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, gynecology and pathological anatomy. Autologous platelet-enriched blood plasma is used, while the preparation of the endometrium of the patient is performed using a standardized protocol of hormone replacement therapy against the background of monitoring the growth of the endometrium, from 3/4 days of the cycle prescribe estradiolavalerate 2 mg 2 times a day and transdermal form of estradiol in the starting dose of 1.25 g 2 times a day. As a support for the luteal phase, micronized progesterone is used vaginally at a daily dose of 90 mg and progesterone oil solution 1 % – 1 ml intramuscularly once a day. Moreover, the transfer of viable embryos is performed on the 6^th day of administration of progesterone, and on the 10/11 day of the cycle, after ultrasonic evaluation of the thickness of the endometrium, intrauterine perfusion of 1.0–1.5 ml of an autologous blood plasma enriched with platelets is carried out using an insemination catheter.

EFFECT: method increases the expression of growth factors in the endometrium, that leads to an increase in the thickness of the endometrium and an increased likelihood of a successful outcome of assisted reproductive technology.

1 cl, 1 tbl, 2 dwg