FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions relates to medicine and pharmaceutics and can be used to treat inflammatory bowel disease. Disclosed is a method of treating or slowing the progression of inflammatory bowel disease in a mammal, comprising administering an effective amount of a CCR9 chemokine receptor inhibitor in a combination with an effective amount of an integrin blocking antibody α4β7, wherein the CCR9 chemokine receptor inhibitor is vercirnone, and the integrin blocking antibody α4β7 is vedolizumab. Also disclosed is a kit for treating or slowing down the progression of inflammatory bowel disease in a mammal, comprising a therapeutically effective amount of a CCR9 chemokine receptor inhibitor, which is vercirnone, and a therapeutically effective amount of an integrin blocking antibody α4β7, which is vedolizumab, with instructions for effective use.
EFFECT: group of inventions provides a synergistic action of a combination of vercirnone and vedolizumab in treating inflammatory bowel disease.
9 cl, 5 dwg, 1 ex
| Title | Year | Author | Number |
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|
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|
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| REDUCTION OF TUMOR MASS BY INJECTING CCR1 ANTAGONISTS IN COMBINATION WITH PD-1 INHIBITORS OR PD-L1 INHIBITORS | 2017 |
|
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| 2-OXINDOLE COMPOUNDS | 2017 |
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| METHOD OF IMPROVING CONDITION OF DIGESTIVE SYSTEM | 2020 |
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| HOMODETIC CYCLIC PEPTIDES SPECIFICALLY ACTING ON α4β7 INTEGRIN | 2018 |
|
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