FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to the pharmaceutical industry, in particular to a method for producing a semi-synthetic hybrid material from a natural hybrid biomaterial. A method for manufacturing a semi-synthetic natural hybrid biomaterial, which is a pearlescent aragonite layer of bivalve mollusks selected from the group consisting of Pinctada maxima, Pinctada margaritifera, Tridacnae maxima, Tridacnae gigas and other Pinctadas, which contains an inorganic fraction and an organic fraction, the method comprising a pH change step and a crosslinking step of the organic fraction of said natural hybrid biomaterial, wherein the step of modifying the pH is carried out by immersing the natural hybrid biomaterial in a bath with microbiologically controlled tap water brought to the boiling point to obtain the desired pH, the step of crosslinking is carried out with a cross-linking agent and / or physical agents, under certain conditions. Semi-synthetic hybrid material. A method of manufacturing a device or an implant for osteosynthesis made of a semi-synthetic hybrid material. Device or implant for osteosynthesis.
EFFECT: invention described above makes it possible to obtain a material for osteosynthesis that can be stored permanently at the fracture site and is an alternative to a metallic material for osteosynthesis.
9 cl, 13 ex, 12 dwg
