PREPARATION METHODS FOR A NOVEL GENERATION OF BIOLOGICAL SAFE KLH PRODUCTS USED FOR CANCER TREATMENT, FOR THE DEVELOPMENT OF CONJUGATED THERAPEUTIC VACCINES AND AS CHALLENGING AGENTS Russian patent published in 2018 - IPC A61K35/68 A61K35/63 C07K14/435 

Abstract RU 2672105 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for the preparation of a synthetic fissurella hemocyanin (KLH). Method of producing fissurella hemocyanin (KLH) comprising the steps of: a) dissociating native KLH to obtain sub-units, b) nanofiltrating the sub-units obtained in step a) using filters with a pore size between 15 and 35 nm; and c) associating the sub-units obtained after nanofiltering to obtain the synthetic KLH. Method of producing immunocyanin. Synthetic fissurella hemocyanin (KLH), obtained by the above method. Synthetic immunocyanin obtained by the above method. Method of removing virus from a hemocyanin preparation.

EFFECT: described method allows obtaining synthetic hemocyanin and immunocyanin of fissurella, with a high purification degree.

20 cl, 6 ex

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RU 2 672 105 C2

Authors

Kottvits Ortvin

Shtifel Tomas

Muddukrishna Shammana N.

Dates

2018-11-12Published

2014-06-12Filed