PREDICTIVE BIOMARKER FOR CANCER THERAPY Russian patent published in 2018 - IPC G01N33/574 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely, the prediction or monitoring of the future or current response of a patient suffering from cancer to a TLR-9 agonist treatment. For this purpose, the frequency of activated natural killer T (NKT) cells is determined, where the patient responding to the TLR-9 agonist treatment has a frequency of at least 3 % activated NKT cells of the whole NKT cell population. At the same time, the patient responding to treatment has a prolonged survival time without progression. Further, the TLR-9 agonist is a DNA construct from a covalently continuous, partially self-complementary DNA strand having a double-stranded stem with single-stranded end loops bearing unmethylated CG motif, wherein the DNA construct comprises at least one sequence motif N¹N²CGN³N⁴, where N¹N² and N³N⁴ represent any combination of A, C, T and G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine, and T is deoxythymidine. Also, the group of inventions relates to the use of a TLR-9 agonist representing a DNA construct for the treatment of cancer.

EFFECT: use of this group of inventions allows the use of activated NKT cells as a biomarker for patients undergoing TLR-9 agonist treatment.

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